Spinosad has a mode of action different from the older compounds presently used for the treatment of head lice.
Salgado et al ( Appendix 4 Part A Part B ) has reported that Spinosyn A directly excites the nervous system,
initially causing involuntary muscle contractions and tremors by acting on the neurons in the central nervous system of the insect.
Insects treated with Spinosyn A are eventually paralyzed, but only after prolonged periods of excitation,
suggesting that paralysis is not a primary effect, but instead is a secondary effect resulting from the prolonged over excitation of the nervous system.
Further, excitation of the insect nervous system by Spinosyn A appears related to alteration of the function of nicotinic and gamma amino butyric acid (GABA)–gated ion channels.
However, Spinosyn A does not interact within known binding sites for other nicotinic or GABA-gated insecticides. This appears to be the basis for the unique insecticidal mechanism and lack of cross-resistance with other insecticides.
In summary, as stated in the Spinosad Technical Bulletin, “Continuous activation of motor neurons causes insects to die of exhaustion.”
Ask your doctor if Natroba Topical Suspension is right for you or your child.
INDICATION
Natroba Topical Suspension is a pediculicide indicated for the topical treatment of head lice infestations in patients four (4) years of age and older.
IMPORTANT SAFETY INFORMATION
Natroba Topical Suspension contains benzyl alcohol and is not recommended for use in neonates and infants below the age of 6 months. Systemic
exposure to benzyl alcohol has been associated with serious adverse reactions and death in neonates and low birth-weight infants.
Most common adverse events were: application site redness (3%), redness and irritation of the eyes (2%) and application site irritation (1%).
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.